Using optical coherence tomography to monitor effects of electromechanical reshaping in septal cartilage

Heather Chen; Lingfeng Yu; Cyrus Manuel; Brian J. F. Wong

doi:10.1117/12.847477

2 March 2010 Using optical coherence tomography to monitor effects of electromechanical reshaping in septal cartilage

Heather Chen, Lingfeng Yu, Cyrus Manuel, Brian J. F. Wong

Proceedings Volume 7548, Photonic Therapeutics and Diagnostics VI; 75482J (2010) https://doi.org/10.1117/12.847477
Event: SPIE BiOS, 2010, San Francisco, California, United States

Abstract

Electromechanical reshaping (EMR) of cartilage is a promising noninvasive technique with potential for broad application in reconstructive surgery. EMR involves applying direct current electrical fields to localized stress regions and initiating a series of oxidation-reduction reactions, thus effecting a shape change. Previous EMR studies have focused on macroscopic structural measurements of the shape change effect or monitoring of electrical current flow. Only limited investigation of structural changes in the tissue at the histologic level have been performed, and not in real time. This study is the first to use optical coherence tomography (OCT) to examine structural changes in cartilage during EMR. Two platinum needle electrodes were inserted into fixed rectangular rabbit nasal septal cartilage specimens. The spectral domain OCT probe was then positioned above the section of cartilage in which the anode needle was inserted. A constant voltage of 6V was applied for 3 minutes, and images were obtained (8 frames/second). OCT was also performed in specimens undergoing dehydration under ambient conditions and during pH changes produced by the addition of HCl, as both processes accompany EMR. The OCT data identified distinct findings among the three conditions, suggesting that EMR causes a much greater degree of reshaping on a molecular level than dehydration or a change in pH alone. OCT provides a means to gauge structural changes in the tissue matrix during EMR. The application of OCT to image the EMR process will add to our understanding of the mechanisms of action involved and potentially facilitate optimization of this process.

Citation Download Citation

Heather Chen, Lingfeng Yu, Cyrus Manuel, and Brian J. F. Wong "Using optical coherence tomography to monitor effects of electromechanical reshaping in septal cartilage", Proc. SPIE 7548, Photonic Therapeutics and Diagnostics VI, 75482J (2 March 2010); https://doi.org/10.1117/12.847477

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
5 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Optical coherence tomography

Cartilage

Image processing

Tissues

Surgery

Platinum

Tissue optics

Show All Keywords

Keywords/Phrases

Search In:

Publication Years