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Proceedings Article

Small animal ocular biometry using optical coherence tomography

[+] Author Affiliations
Marco Ruggeri, Omer Kocaoglu, Stephen Uhlhorn, David Borja, Raksha Urs, Tsung-Han Chou, Fabrice Manns

Bascom Palmer Eye Institute, Univ. of Miami Miller School of Medicine (USA) and Biomedical Optics Lab., Univ. of Miami (USA)

Vittorio Porciatti

Bascom Palmer Eye Institute, Univ. of Miami Miller School of Medicine (USA)

Jean-Marie Parel

Bascom Palmer Eye Institute, Univ. of Miami Miller School of Medicine (USA) and Biomedical Optics Lab., Univ. of Miami (USA) and Vision Cooperative Research Ctr. (Australia)

Proc. SPIE 7550, Ophthalmic Technologies XX, 755016 (March 02, 2010); doi:10.1117/12.846937
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From Conference Volume 7550

  • Ophthalmic Technologies XX
  • Fabrice Manns; Per G. Söderberg; Arthur Ho
  • San Francisco, California | January 23, 2010

abstract

A custom-built OCT system was used to obtain images of the whole mouse eye. We developed a semi-automated segmentation method to detect the boundaries of the anterior and posterior corneal, lens and retinal surfaces as well as the anterior surface of the iris. The radii of curvature of the surfaces were calculated using a conic section fit of each boundary. Image distortions due to refraction of the OCT beam at the successive boundaries were corrected using a ray-tracing algorithm. Corrected ocular distances, radii of curvature of the cornea and lens surfaces, and anterior chamber angle were obtained on 3 C57BL/6J mice. In vivo imaging of the whole eye, segmentation, conic function fits and correction were successful in all three animals. The posterior lens surface of one mouse could not be fit accurately with a conic section. Biometric parameters of C57BL/6J mice compared well with previous published data obtained from histological sections. The study demonstrates the feasibility of quantitative in vivo biometry of mouse models.

© (2010) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.
Citation

Marco Ruggeri ; Omer Kocaoglu ; Stephen Uhlhorn ; David Borja ; Raksha Urs, et al.
"Small animal ocular biometry using optical coherence tomography", Proc. SPIE 7550, Ophthalmic Technologies XX, 755016 (March 02, 2010); doi:10.1117/12.846937; http://dx.doi.org/10.1117/12.846937


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