Can dendritic cells see light?

Aaron C.-H. Chen; Ying-Ying Huang; Sulbha K. Sharma; Michael R. Hamblin

doi:10.1117/12.842959

25 February 2010 Can dendritic cells see light?

Aaron C.-H. Chen, Ying-Ying Huang, Sulbha K. Sharma, Michael R. Hamblin

Proceedings Volume 7565, Biophotonics and Immune Responses V; 756504 (2010) https://doi.org/10.1117/12.842959
Event: SPIE BiOS, 2010, San Francisco, California, United States

Abstract

There are many reports showing that low-level light/laser therapy (LLLT) can enhance wound healing, upregulate cell proliferation and has anti-apoptotic effects by activating intracellular protective genes. In the field of immune response study, it is not known with any certainty whether light/laser is proinflammatory or anti-inflammatory. Increasingly in recent times dendritic cells have been found to play an important role in inflammation and the immunological response. In this study, we try to look at the impact of low level near infrared light (810-nm) on murine bone-marrow derived dendritic cells. Changes in surface markers, including MHC II, CD80 and CD11c and the secretion of interleukins induced by light may provide additional evidence to reveal the mystery of how light affects the maturation of dendritic cells as well how these light-induced mature dendritic cells would affect the activation of adaptive immune response.

Citation Download Citation

Aaron C.-H. Chen, Ying-Ying Huang, Sulbha K. Sharma, and Michael R. Hamblin "Can dendritic cells see light?", Proc. SPIE 7565, Biophotonics and Immune Responses V, 756504 (25 February 2010); https://doi.org/10.1117/12.842959

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