Simultaneously reconstructing fluorescent yield and lifetime from time-resolved transmittances of a small-animal-sized phantom

Feng Gao; Limin Zhang; Patrick Poulet; Jiao Li; Huijuan Zhao; Yukio Yamada

doi:10.1117/12.831670

9 July 2009 Simultaneously reconstructing fluorescent yield and lifetime from time-resolved transmittances of a small-animal-sized phantom

Feng Gao, Limin Zhang, Patrick Poulet, Jiao Li, Huijuan Zhao, Yukio Yamada

Author Affiliations +

Proceedings Volume 7369, Diffuse Optical Imaging II; 73691H (2009) https://doi.org/10.1117/12.831670
Event: European Conferences on Biomedical Optics, 2009, Munich, Germany

Abstract

A full three-dimensional, featured-data algorithm for time-domain diffuse fluorescence tomography is presented, which inverts the Laplace-transformed time-domain coupled diffusion equations and employs a pair of real-domain transform-factors to effectively separate the fluorescent yield and lifetime parameters. By use of a multi-channel time-correlation single photon counting system and a normalized Born formulation for the inversion, the proposed scheme is experimentally validated to achieve simultaneous reconstruction of the fluorescent yield and lifetime distributions with a reasonable accuracy.

Citation Download Citation

Feng Gao, Limin Zhang, Patrick Poulet, Jiao Li, Huijuan Zhao, and Yukio Yamada "Simultaneously reconstructing fluorescent yield and lifetime from time-resolved transmittances of a small-animal-sized phantom", Proc. SPIE 7369, Diffuse Optical Imaging II, 73691H (9 July 2009); https://doi.org/10.1117/12.831670

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KEYWORDS

Luminescence

Signal detection

Diffusion

Atrial fibrillation

Image restoration

Optical filters

Optical properties

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