Fourier-domain angle-resolved low coherence interferometry for clinical detection of dysplasia

Neil G. Terry; Yizheng Zhu; Adam Wax

doi:10.1117/12.842464

26 February 2010 Fourier-domain angle-resolved low coherence interferometry for clinical detection of dysplasia

Neil G. Terry, Yizheng Zhu, Adam Wax

Proceedings Volume 7573, Biomedical Applications of Light Scattering IV; 75730P (2010) https://doi.org/10.1117/12.842464
Event: SPIE BiOS, 2010, San Francisco, California, United States

Abstract

Improved methods for detecting dysplasia, or pre-cancerous growth are a current clinical need, particularly in the esophagus. The currently accepted method of random biopsy and histological analysis provides only a limited examination of tissue in question while being coupled with a long time delay for diagnosis. Light scattering spectroscopy, in contrast, allows for inspection of the cellular structure and organization of tissue in vivo. Fourier-domain angle-resolved low-coherence interferometry (a/LCI) is a novel light scattering spectroscopy technique that provides quantitative depth-resolved morphological measurements of the size and optical density of the examined cell nuclei, which are characteristic biomarkers of dysplasia. Previously, clinical viability of the a/LCI system was demonstrated through analysis of ex vivo human esophageal tissue in Barrett's esophagus patients using a portable a/LCI, as was the development of a clinical a/LCI system. Data indicating the feasibility of the technique in other organ sites (colon, oral cavity) will be presented. We present an adaptation of the a/LCI system that will be used to investigate the presence of dysplasia in vivo in Barrett's esophagus patients.

Citation Download Citation

Neil G. Terry, Yizheng Zhu, and Adam Wax "Fourier-domain angle-resolved low coherence interferometry for clinical detection of dysplasia", Proc. SPIE 7573, Biomedical Applications of Light Scattering IV, 75730P (26 February 2010); https://doi.org/10.1117/12.842464

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KEYWORDS

Light scattering

Esophagus

Tissue optics

Interferometry

Scattering

Spectroscopy

Endoscopes

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