Gold nanoprobes for multi-modality tumor imaging

James Nyagilo; Ming Xiao; Xiankai Sun; Digant P. Davé

doi:10.1117/12.842917

1 March 2010 Gold nanoprobes for multi-modality tumor imaging

James Nyagilo, Ming Xiao, Xiankai Sun, Digant P. Davé

Proceedings Volume 7576, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications II; 75760X (2010) https://doi.org/10.1117/12.842917
Event: SPIE BiOS, 2010, San Francisco, California, United States

Abstract

Gold nanoparticles have been shown to possess x-ray attenuation higher than that of clinically used iodine based contrast agents. Additionally, gold nanoparticles have also been used in enhancing the Raman signal through a phenomenon called Surface Enhanced Raman Scattering (SERS). The development of Gold nanoparticle based probes (nanotags) for combined SERS and x-ray computed tomography (CT) are reported. These nanotags comprise quasi-spherical gold nanoparticles encoded using a Raman active molecule and encapsulated by a monolayer of polyethylene glycol with carboxylate functional groups for bioconjugation. The nanotags, made from ~65 nm gold nanoparticles, display large SERS cross-section and x-ray absorption which are used for dual modality imaging of tumor cells in of an orthotropic prostate cancer tumor animal model.

Citation Download Citation

James Nyagilo, Ming Xiao, Xiankai Sun, and Digant P. Davé "Gold nanoprobes for multi-modality tumor imaging", Proc. SPIE 7576, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications II, 75760X (1 March 2010); https://doi.org/10.1117/12.842917

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