Femtosecond laser microstructuring of titanium surfaces for middle ear ossicular replacement prosthesis: results of preliminary studies

S. Biedron; J. F. R. Ilgner; E. Fadeeva; B. Chichkov; A. Prescher; M. Bovi; M. Westhofen

doi:10.1117/12.831883

17 July 2009 Femtosecond laser microstructuring of titanium surfaces for middle ear ossicular replacement prosthesis: results of preliminary studies

S. Biedron, J. F. R. Ilgner, E. Fadeeva, B. Chichkov, A. Prescher, M. Bovi, M. Westhofen

Author Affiliations +

Proceedings Volume 7373, Therapeutic Laser Applications and Laser-Tissue Interactions IV; 73731A (2009) https://doi.org/10.1117/12.831883
Event: European Conferences on Biomedical Optics, 2009, Munich, Germany

Abstract

The objective of this study was to optimize titanium surfaces by means of Ti:Sapphire femtosecond laser to improve the attachment of human cartilage cells on titanium prosthesis in middle ear surgery. The application of microstructures on titanium samples was evaluated and the influence of these microstructures on human auricular chondrocytes was studied in-vitro. After establishing the ear chondrocyte cell culture, cells were seeded on titanium platelets with selected microstructure patterns. Whereas the phenotype of cells seeded on unstructured titanium was similar to cells grown on standard tissue culture surfaces, the morphology of chondrocytes grown on structured titanium samples was influenced by the pattern. For future titanium middle ear prosthesis structural optimizations will be developed to promote chondrocyte growth and adhesion while impeding fibrocyte proliferation to avoid scarring on implant interfaces.

Citation Download Citation

S. Biedron, J. F. R. Ilgner, E. Fadeeva, B. Chichkov, A. Prescher, M. Bovi, and M. Westhofen "Femtosecond laser microstructuring of titanium surfaces for middle ear ossicular replacement prosthesis: results of preliminary studies", Proc. SPIE 7373, Therapeutic Laser Applications and Laser-Tissue Interactions IV, 73731A (17 July 2009); https://doi.org/10.1117/12.831883

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available