Palliative photodynamic therapy for biliary tract carcinoma may improve survival and has a similar outcome to attempted curative surgery with positive resection margins

Stephen P. Pereira; W. Rudiger Matull; Dipok K. Dhar; Laskshmana Ayaru; Neomal S. Sandanayake; Michael H. Chapman

doi:10.1117/12.828450

13 July 2009 Palliative photodynamic therapy for biliary tract carcinoma may improve survival and has a similar outcome to attempted curative surgery with positive resection margins

Stephen P. Pereira, W. Rudiger Matull, Dipok K. Dhar, Laskshmana Ayaru, Neomal S. Sandanayake, Michael H. Chapman

Author Affiliations +

Proceedings Volume 7380, Photodynamic Therapy: Back to the Future; 73800V (2009) https://doi.org/10.1117/12.828450
Event: 12th World Congress of the International Photodynamic Association, 2009, Seattle, Washington, United States

Abstract

There is a need for better management strategies to improve survival and quality of life in patients with biliary tract cancer (BTC). We compared treatment outcomes in 321 patients (median age 65 years, range 29-102; F:M; 1:1) with a final diagnosis of BTC (cholangiocarcinoma n=237, gallbladder cancer n=84) seen in a tertiary referral cancer centre between 1998-2007. Of 89 (28%) patients who underwent surgical intervention with curative intent, 38% had R0 resections and had the most favourable outcome, with a 3 year survival of 57%. Even though PDT patients had more advanced clinical T-stages, their survival was similar to those treated with attempted curative surgery which resulted in R1/2 resections (median survival 12 vs. 13 months, ns). In a subgroup of 36 patients with locally advanced BTC treated with PDT as part of a prospective phase II study, the median survival was 12 (range 2-51) months, compared with 5 months in matched historical controls treated with stenting alone (p < 0.0001). In this large UK series, long-term survival with BTC was only achieved in surgical patients with R0 resection margins. Palliative PDT resulted in similar survival to those with curatively intended R1/R2 resections.

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Stephen P. Pereira, W. Rudiger Matull, Dipok K. Dhar, Laskshmana Ayaru, Neomal S. Sandanayake, and Michael H. Chapman "Palliative photodynamic therapy for biliary tract carcinoma may improve survival and has a similar outcome to attempted curative surgery with positive resection margins", Proc. SPIE 7380, Photodynamic Therapy: Back to the Future, 73800V (13 July 2009); https://doi.org/10.1117/12.828450

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KEYWORDS

Photodynamic therapy

Surgery

Radiotherapy

Control systems

Cancer

Biliary tract cancer

Gallbladder

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