Catheter-based complex swept source optical coherence tomography for biomedical imaging

Youxin Mao; Costel Flueraru; Shoude Chang

doi:10.1117/12.828233

13 July 2009 Catheter-based complex swept source optical coherence tomography for biomedical imaging

Youxin Mao, Costel Flueraru, Shoude Chang

Proceedings Volume 7380, Photodynamic Therapy: Back to the Future; 73806Q (2009) https://doi.org/10.1117/12.828233
Event: 12th World Congress of the International Photodynamic Association, 2009, Seattle, Washington, United States

Abstract

We demonstrate a catheter-based complex swept-source optical coherence tomography (SS-OCT) system using a 3x3 Mach-Zehnder quadrature interferometer and an ultra-small optic probe. Design and fabrication of fiber lens for ultrasmall optic probes are presented first. We compare in detail measured performance with expected theoretical performance. Then, we present a 3x3 Mach-Zehnder quadrature interferometer to acquire a complex interferometric signal for SS-OCT. We introduce an unbalanced differential detection method to improve the overall utilization of optical power and provide simultaneous access to the complementary phase components of the complex interferometric signal. No calculations by trigonometric relationships are needed. We compare the performance for our setup to that of a similar interferometer with a commonly used balanced detection technique. We demonstrate complex conjugate artifact suppression of 27 dB obtained in our swept-source optical coherence tomography using our unbalanced differential detection. OCT in vivo and ex vivo images shown in this presentation indicate that our catheter-based complex SS-OCT system is capable for imaging of biomedical tissues and inside organs for human, small animals and big animals.

Citation Download Citation

Youxin Mao, Costel Flueraru, and Shoude Chang "Catheter-based complex swept source optical coherence tomography for biomedical imaging", Proc. SPIE 7380, Photodynamic Therapy: Back to the Future, 73806Q (13 July 2009); https://doi.org/10.1117/12.828233

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KEYWORDS

GRIN lenses

Optical coherence tomography

Biomedical optics

Imaging systems

Signal detection

Tissue optics

Tissues

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