Spatial mapping of oxygen levels in the brain using a digital micromirror device

Andrew K. Dunn; Adrien Ponticorvo

doi:10.1117/12.845283

18 February 2010 Spatial mapping of oxygen levels in the brain using a digital micromirror device

Andrew K. Dunn, Adrien Ponticorvo

Proceedings Volume 7596, Emerging Digital Micromirror Device Based Systems and Applications II; 759606 (2010) https://doi.org/10.1117/12.845283
Event: SPIE MOEMS-MEMS, 2010, San Francisco, California, United States

Abstract

Mapping of absolute oxygen levels in the brain is critical during stroke and other disorders. One of the standard methods for measuring oxygen tension is through oxygen dependent quenching of phosphorescence. Typically these measurements are limited to a single spatial location due to the need to measure phosphorescence lifetimes. We have developed an instrument to obtain spatial maps oxygen tension in the brain by combining a DMD with phosphorescence lifetime measurements. Blood flow is measured simultaneously with laser speckle contrast imaging. In this paper we describe this instrument and demonstrate its use in studying stroke progression in animal models.

Citation Download Citation

Andrew K. Dunn and Adrien Ponticorvo "Spatial mapping of oxygen levels in the brain using a digital micromirror device", Proc. SPIE 7596, Emerging Digital Micromirror Device Based Systems and Applications II, 759606 (18 February 2010); https://doi.org/10.1117/12.845283

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