Laser speckle and skin cancer: skin roughness assessment

Tim K. Lee; Lioudmila Tchvialeva; Haishan Zeng; David I. McLean; Harvey Lui

doi:10.1117/12.854001

31 December 2009 Laser speckle and skin cancer: skin roughness assessment

Tim K. Lee, Lioudmila Tchvialeva, Haishan Zeng, David I. McLean, Harvey Lui

Proceedings Volume 7388, Ninth International Conference on Correlation Optics; 738816 (2009) https://doi.org/10.1117/12.854001
Event: Correlation Optics 2009, 2009, Chernivsti, Ukraine

Abstract

Incidence of skin cancer has been increasing rapidly since the last few decades. Non-invasive optical diagnostic tools may improve the diagnostic accuracy. In this paper, skin structure, skin cancer statistics and subtypes of skin cancer are briefly reviewed. Among the subtypes, malignant melanoma is the most aggressive and dangerous; early detection dramatically improves the prognosis. Therefore, a non-invasive diagnostic tool for malignant melanoma is especially needed. In addition, in order for the diagnostic tool to be useful, it must be able to differentiate melanoma from common skin conditions such as seborrheic keratosis, a benign skin disease that resembles melanoma according to the well known clinical-assessment ABCD rule. The key diagnostic feature between these two diseases is surface roughness. Based on laser speckle contrast, our research team has recently developed a portable, optical, non-invasive, in-vivo diagnostic device for quantifying skin surface roughness. The methodology of our technique is described in details. Examining the preliminary data collected in a pilot clinical study for the prototype, we found that there was a difference in roughness between melanoma and seborrheic keratosis. In fact, there was a perfect cutoff value for the two diseases based on our initial data.

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Tim K. Lee, Lioudmila Tchvialeva, Haishan Zeng, David I. McLean, and Harvey Lui "Laser speckle and skin cancer: skin roughness assessment", Proc. SPIE 7388, Ninth International Conference on Correlation Optics, 738816 (31 December 2009); https://doi.org/10.1117/12.854001

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