Glucose sensing using 3D array of reproducible surface enhanced Raman scattering substrates

Dinish U. S; Chit Yaw Fu; Ajay Agarwal; Praveen Thoniyot; Malini Olivo

doi:10.1117/12.827228

21 August 2009 Glucose sensing using 3D array of reproducible surface enhanced Raman scattering substrates

Dinish U. S, Chit Yaw Fu, Ajay Agarwal, Praveen Thoniyot, Malini Olivo

Proceedings Volume 7397, Biosensing II; 73970C (2009) https://doi.org/10.1117/12.827228
Event: SPIE NanoScience + Engineering, 2009, San Diego, California, United States

Abstract

Surface Enhanced Raman Scattering (SERS) technique is used as an indispensable and sensitive modality for bio-sensing due to its ability to distinguish the analyte molecules based on their distinct 'fingerprint' spectra. One of the most promising SERS substrates for biosensing was fabricated by coating noble metal film over orderly packed nanospheres. However, the major challenge in developing such a sensor is to achieve reproducible SERS substrate. Here, we report a new class of SERS substrate with ordered 3D nanostructures fabricated on silicon wafer by deep UV lithography technique followed by bi-metallic coating of silver and gold. Compared to the substrate fabricated by conventional nanosphere lithography, this approach allows better control of the nanostructures, which in turn gives uniform surface roughness for the metal film to provide adequate SERS enhancement with high reproducibility. Significance of this substrate for biomedical application was demonstrated by glucose sensing under physiologically relevant conditions. Partitioning and localization of glucose molecules within the first few nanometers of active SERS substrate was achieved by a self assembled monolayer (SAM) on the surface of substrate.

Citation Download Citation

Dinish U. S, Chit Yaw Fu, Ajay Agarwal, Praveen Thoniyot, and Malini Olivo "Glucose sensing using 3D array of reproducible surface enhanced Raman scattering substrates", Proc. SPIE 7397, Biosensing II, 73970C (21 August 2009); https://doi.org/10.1117/12.827228

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available