A micro hemoglobin-A1c immunosensor based on FET and electrochemical growth of gold nanoparticles

Lan Qu; Chao Bian; Jizhou Sun; Jinghong Han; Shanhong Xia

doi:10.1117/12.807112

2 February 2009 A micro hemoglobin-A1c immunosensor based on FET and electrochemical growth of gold nanoparticles

Lan Qu, Chao Bian, Jizhou Sun, Jinghong Han, Shanhong Xia

Proceedings Volume 7159, 2008 International Conference on Optical Instruments and Technology: MEMS/NEMS Technology and Applications; 715908 (2009) https://doi.org/10.1117/12.807112
Event: International Conference of Optical Instrument and Technology, 2008, Beijing, China

Abstract

A micro potentiometric hemoglobin-A1c (HbA1c) immunosensor based on field-effect transistor (FET) and electrochemical growth of gold nanoparticles (AuNPs) in polypyrrole (PPy) film is reported. Integrated ion-sensitive field-effect transistors (ISFETs) chips containing two ISFETs, two reference FETs (REFET) and the signal read-out circuits were fabricated. Micro electrodes of the sensor were fabricated by MEMS techniques and electrochemical method, both compatible with electrode miniaturization. The simple and direct procedure to form PPy-AuNPs composite film enhances the sensitivity of the micro sensor. Electrochemical characterization and morphology study by scanning electron microscopy (SEM) confirm the presence of AuNPs in PPy. Simple, rapid and precise differential measurement of HbA1c is achieved. HbA1c in the concentration ranges of 2-20 ng/ml and 4-15 µg/ml can be detected by this sensor with a response time less than 1 min, which meets the needs of clinical detection of HbA1c. The miniaturized electrodes and integrated ISFET chip have the potential to be integrated and to achieve system on chip (SOC).

Citation Download Citation

Lan Qu, Chao Bian, Jizhou Sun, Jinghong Han, and Shanhong Xia "A micro hemoglobin-A1c immunosensor based on FET and electrochemical growth of gold nanoparticles", Proc. SPIE 7159, 2008 International Conference on Optical Instruments and Technology: MEMS/NEMS Technology and Applications, 715908 (2 February 2009); https://doi.org/10.1117/12.807112

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available