MRI-guided fluorescence tomography of the breast: a phantom study

Scott C. Davis; Brian W. Pogue; Hamid Dehghani; Keith D. Paulsen

doi:10.1117/12.809735

20 February 2009 MRI-guided fluorescence tomography of the breast: a phantom study

Scott C. Davis, Brian W. Pogue, Hamid Dehghani, Keith D. Paulsen

Proceedings Volume 7171, Multimodal Biomedical Imaging IV; 71710I (2009) https://doi.org/10.1117/12.809735
Event: SPIE BiOS, 2009, San Jose, California, United States

Abstract

Tissue phantoms simulating the human breast were used to demonstrate the imaging capabilities of an MRI-coupled fluorescence molecular tomography (FMT) imaging system. Specifically, phantoms with low tumor-to-normal drug contrast and complex internal structure were imaged with the MR-coupled FMT system. Images of indocyanine green (ICG) fluorescence yield were recovered using a diffusion model-based approach capable of estimating the distribution of fluorescence activity in a tissue volume from tissue-boundary measurements of transmitted light. Tissue structural information, which can be determined from standard T1 and T2 MR images, was used to guide the recovery of fluorescence activity. The study revealed that this spatial guidance is critical for recovering images of fluorescence yield in tissue with low tumor-to-normal drug contrast.

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Scott C. Davis, Brian W. Pogue, Hamid Dehghani, and Keith D. Paulsen "MRI-guided fluorescence tomography of the breast: a phantom study", Proc. SPIE 7171, Multimodal Biomedical Imaging IV, 71710I (20 February 2009); https://doi.org/10.1117/12.809735

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KEYWORDS

Luminescence

Tumors

Tissues

Tissue optics

Magnetic resonance imaging

Breast

Fluorescence tomography

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