Selective inactivation of human immunodeficiency virus with an ultrashort pulsed laser

K. T. Tsen; Shaw-Wei D. Tsen; Chien-Fu Hung; T.-C. Wu; Karen Kibler; Bert Jacobs; Juliann G. Kiang

doi:10.1117/12.808532

12 February 2009 Selective inactivation of human immunodeficiency virus with an ultrashort pulsed laser

K. T. Tsen, Shaw-Wei D. Tsen, Chien-Fu Hung, T.-C. Wu, Karen Kibler, Bert Jacobs, Juliann G. Kiang

Proceedings Volume 7175, Optical Interactions with Tissue and Cells XX; 717510 (2009) https://doi.org/10.1117/12.808532
Event: SPIE BiOS, 2009, San Jose, California, United States

Abstract

Recently, femtosecond laser technology has been shown to be effective in the inactivation of non-pathogenic viruses. In this paper, we demonstrate for the first time that infectious numbers of pathogenic viruses such as Human Immunodeficiency Virus (HIV) can be reduced by irradiation with subpicosecond near infrared laser pulses at a moderate laser power density. By comparing the threshold laser power density for the inactivation of HIV with those of human red blood cells and mouse dendritic cells, we conclude that it is plausible to use the ultrashort pulsed laser to selectively inactivate blood-borne pathogens such as HIV while leaving the sensitive materials like human red blood cells unharmed. This finding has important implications in the development of a new laser technology for disinfection of viral pathogens in blood products and in the clinic.

Citation Download Citation

K. T. Tsen, Shaw-Wei D. Tsen, Chien-Fu Hung, T.-C. Wu, Karen Kibler, Bert Jacobs, and Juliann G. Kiang "Selective inactivation of human immunodeficiency virus with an ultrashort pulsed laser", Proc. SPIE 7175, Optical Interactions with Tissue and Cells XX, 717510 (12 February 2009); https://doi.org/10.1117/12.808532

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