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Proceedings Article

Photoacoustic temperature measurements for monitoring of thermal therapy

[+] Author Affiliations
Shiou-Han Wang

National Taiwan Univ. (Taiwan) and National Taiwan Univ. Hospital (Taiwan)

Chen-Wei Wei, Pai-Chi Li

National Taiwan Univ. (Taiwan)

Shiou-Hwa Jee

National Taiwan Univ. Hospital (Taiwan)

Proc. SPIE 7177, Photons Plus Ultrasound: Imaging and Sensing 2009, 71771S (February 12, 2009); doi:10.1117/12.809973
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From Conference Volume 7177

  • Photons Plus Ultrasound: Imaging and Sensing 2009
  • Alexander A. Oraevsky; Lihong V. Wang
  • San Jose, CA | January 24, 2009

abstract

Plasmonic photothermal therapy is a new cancer thermotherapy method based on surface plasmon resonance of nanoparticles. It is important to measure the temperature during thermotherapy for safety and efficacy. In this study, we apply a photoacoustic (PA) method for real-time, non-invasive temperature measurements. In particular, this method can be effectively combined with a photothermal therapy system that we developed in parallel. The method is based on the fact that the PA pressure amplitude is linearly related to temperature. To explore its potential, a home-made, 20 MHz PA transducer was used, in which an optical fiber was inserted in its center for emitting laser pulses while the PA signal was simultaneously detected. Continuous wave (CW) laser was used to heat the subject, including both phantoms and mice. The temperature of the region of interest was also measured by a fine-needle thermal couple. Results show that the temperature was linearly proportional to the PA signal with good correlation with the CW laser irradiation. The in vivo study also demonstrated potential of this technique.

© (2009) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.
Citation

Shiou-Han Wang ; Chen-Wei Wei ; Shiou-Hwa Jee and Pai-Chi Li
"Photoacoustic temperature measurements for monitoring of thermal therapy", Proc. SPIE 7177, Photons Plus Ultrasound: Imaging and Sensing 2009, 71771S (February 12, 2009); doi:10.1117/12.809973; http://dx.doi.org/10.1117/12.809973


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