Clinical multiphoton tomography and clinical two-photon microendoscopy

Karsten König; Rainer Bückle; Martin Weinigel; Peter Elsner; Martin Kaatz

doi:10.1117/12.813395

25 February 2009 Clinical multiphoton tomography and clinical two-photon microendoscopy

Karsten König, Rainer Bückle, Martin Weinigel, Peter Elsner, Martin Kaatz

Proceedings Volume 7183, Multiphoton Microscopy in the Biomedical Sciences IX; 718319 (2009) https://doi.org/10.1117/12.813395
Event: SPIE BiOS, 2009, San Jose, California, United States

Abstract

We report on applications of high-resolution clinical multiphoton tomography based on the femtosecond laser system DermaInspect^TM with its flexible mirror arm in Australia, Asia, and Europe. Applications include early detection of melanoma, in situ tracing of pharmacological and cosmetical compounds including ZnO nanoparticles in the epidermis and upper dermis, the determination of the skin aging index SAAID as well as the study of the effects of anti-aging products. In addition, first clinical studies with novel rigid high-NA two-photon 1.6 mm GRIN microendoscopes have been conducted to study the effect of wound healing in chronic wounds (ulcus ulcera) as well as to perform intrabody imaging with subcellular resolution in small animals.

Citation Download Citation

Karsten König, Rainer Bückle, Martin Weinigel, Peter Elsner, and Martin Kaatz "Clinical multiphoton tomography and clinical two-photon microendoscopy", Proc. SPIE 7183, Multiphoton Microscopy in the Biomedical Sciences IX, 718319 (25 February 2009); https://doi.org/10.1117/12.813395

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