Full Content is available to subscribers

Subscribe/Learn More  >
Proceedings Article

Monitoring breast masses with ultrasound tomography in patients undergoing neoadjuvant chemotherapy

[+] Author Affiliations
Jessica Lupinacci, Neb Duric, Peter Littrup, Ding Wang, Cuiping Li, Steven Schmidt, Olsi Rama, Lisa Bey-Knight, Lukasz Myc

Karmanos Cancer Institute, Wayne State Univ. (USA)

Proc. SPIE 7265, Medical Imaging 2009: Ultrasonic Imaging and Signal Processing, 726517 (March 13, 2009); doi:10.1117/12.812975
Text Size: A A A
From Conference Volume 7265

  • Medical Imaging 2009: Ultrasonic Imaging and Signal Processing
  • Stephen A. McAleavey; Jan D'hooge
  • Lake Buena Vista, FL | February 07, 2009

abstract

As part of an ongoing assessment of the in-vivo performance of a operator independent breast imaging device, based on acoustic tomography, we report on new results obtained with patients undergoing neoadjuvant chemotherapy. Five patients were examined with the prototype on multiple occasions corresponding in time to their chemotherapy sessions. Images of reflection, sound speed and attenuation, representing the entire volume of the breast, were reconstructed from the exam data and analyzed for time-dependent changes during the treatment period. It was found that changes in acoustic properties of the tumors could be measured directly from the images. The measured properties include reflectivity, sound speed and attenuation, leading to measurable changes in the volume, shape and internal attributes of the tumors. These measurements were used to monitor the response of the tumors to the therapy with the long term goal of correlating results with pathological and clinical outcomes. Comparisons with tumor size changes based on traditional US and MRI indicates potential for accurate, quantifiable tracking of tumor volume. Furthermore, our tentative results also show declines in internal properties of the tumors, possibly relating to a reduction in tissue stiffness and/or density. Future work will include an expansion of the study to a larger cohort of patients for determining the statistical significance of our findings.

© (2009) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.
Citation

Jessica Lupinacci ; Neb Duric ; Peter Littrup ; Ding Wang ; Cuiping Li, et al.
"Monitoring breast masses with ultrasound tomography in patients undergoing neoadjuvant chemotherapy", Proc. SPIE 7265, Medical Imaging 2009: Ultrasonic Imaging and Signal Processing, 726517 (March 13, 2009); doi:10.1117/12.812975; http://dx.doi.org/10.1117/12.812975


Access This Proceeding
Sign in or Create a personal account to Buy this proceeding ($15 for members, $18 for non-members).

Figures

Tables

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Book Chapters

Topic Collections

Advertisement


 

  • Don't have an account?
  • Subscribe to the SPIE Digital Library
  • Create a FREE account to sign up for Digital Library content alerts and gain access to institutional subscriptions remotely.
Access This Proceeding
Sign in or Create a personal account to Buy this proceeding ($15 for members, $18 for non-members).
Access This Proceeding
Sign in or Create a personal account to Buy this article ($15 for members, $18 for non-members).
Access This Chapter

Access to SPIE eBooks is limited to subscribing institutions and is not available as part of a personal subscription. Print or electronic versions of individual SPIE books may be purchased via SPIE.org.