A polarized light camera (polCAM) is being used to guide surgical excision of skin cancers. Preliminary results of a clinical pilot study are presented. The polCAM uses linearly polarized light and acquires parallel- and cross-polarized images, then the difference image (par - cross) subtracts the background diffusely scattered light and yields an image the unveils the fabric of the skin. Cancer disrupts the complex pattern of this fabric, revealing the cancer margin.© (2008) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.