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Proceedings Article

Dynamic focusing with radial gratings for in vivo high resolution imaging

[+] Author Affiliations
Linbo Liu, Nanguang Chen

National Univ. of Singapore (Singapore)

Proc. SPIE 6847, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine XII, 684718 (February 18, 2008); doi:10.1117/12.760675
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From Conference Volume 6847

  • Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine XII
  • Joseph A. Izatt; James G. Fujimoto; Valery V. Tuchin
  • San Jose, CA | January 19, 2008

abstract

We propose a novel focusing scheme to achieve approximately depth-invariant lateral resolution and signal to noise ratio along an extended axial scanning range for in vivo high-resolution imaging. The pupil function of the objective lens is modulated with a series of radial gratings implemented with a spatial light modulator. Each grating gives rise to a parabolic phase aberration that shifts the focal volume with a pre-defined distance along the optical axis. Dynamic focusing is readily achieved without mechanical translation of sample or focusing optics. With spatial light modulator of higher respond time, images acquired with different focal positions can be fused to retrieve a high-resolution image with depth-invariable lateral resolution and signal to noise ratio.

© (2008) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.
Citation

Linbo Liu and Nanguang Chen
"Dynamic focusing with radial gratings for in vivo high resolution imaging", Proc. SPIE 6847, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine XII, 684718 (February 18, 2008); doi:10.1117/12.760675; http://dx.doi.org/10.1117/12.760675


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