Spectrometer based Fourier domain optical coherence tomography of the mouse retina

Jing Xu; Mohammadali H. Khorasani; Jimmy N. B. Koo; Marinko V. Sarunic

doi:10.1117/12.766069

18 February 2008 Spectrometer based Fourier domain optical coherence tomography of the mouse retina

Jing Xu, Mohammadali H. Khorasani, Jimmy N. B. Koo, Marinko V. Sarunic

Proceedings Volume 6847, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine XII; 684731 (2008) https://doi.org/10.1117/12.766069
Event: SPIE BiOS, 2008, San Jose, California, United States

Abstract

We present a custom Fourier Domain Optical Coherence Tomography (FDOCT) system adapted to imaging the retinal structures in mice. The FDOCT system utilized spectrometer detection, and operated at a central wavelength of 826nm with a FWHM spectral bandwidth of 72nm, corresponding to an axial resolution of ~4microns (in air). A custom hand-held probe was constructed providing adjustable focusing and increased maneuverability over fixed systems to facilitate coupling of the raster scanned beam into the mouse eye. Image acquisition and display was performed in real time using custom written, multi-threaded software package which displays two dimensional B-scans. Cross sectional images of mouse retina, acquired in vivo an anesthetized animals, are presented.

Citation Download Citation

Jing Xu, Mohammadali H. Khorasani, Jimmy N. B. Koo, and Marinko V. Sarunic "Spectrometer based Fourier domain optical coherence tomography of the mouse retina", Proc. SPIE 6847, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine XII, 684731 (18 February 2008); https://doi.org/10.1117/12.766069

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KEYWORDS

Retina

Retinal scanning

Optical coherence tomography

Eye

Spectroscopy

Imaging systems

Speckle

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