In vivo Raman spectroscopy for breast cancer: diagnosis in animal model

R. Bitar; M. A. Martins; D. Ribeiro; C. Carvalho; E. A. P. Santos; L. N. Z. Ramalho; F. Ramalho; H. Martinho; A. A. Martin D.V.M.

doi:10.1117/12.760089

8 February 2008 In vivo Raman spectroscopy for breast cancer: diagnosis in animal model

R. Bitar, M. A. Martins, D. Ribeiro, C. Carvalho, E. A. P. Santos, L. N. Z. Ramalho, F. Ramalho, H. Martinho, A. A. Martin D.V.M.

Author Affiliations +

Proceedings Volume 6853, Biomedical Optical Spectroscopy; 68530O (2008) https://doi.org/10.1117/12.760089
Event: SPIE BiOS, 2008, San Jose, California, United States

Abstract

Raman spectroscopy has been well established as a powerful method for studying biological tissues and diagnosing diseases. In this study we have developed a breast cancer animal model and collected in vivo Raman spectra of mammary glands of 27 Sprague-Dawley female rats treated with DMBA and 5 non-treated used as control group. A dispersive Raman spectrometer with a @785 nm laser excitation coupled a fiber optic probe and a CCD detector was used to obtain the spectra. The obtained in vivo transcutaneous Raman spectra have shown important differences between normal and abnormal tissues when acquired from one side to the other side of the lesion.

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R. Bitar, M. A. Martins, D. Ribeiro, C. Carvalho, E. A. P. Santos, L. N. Z. Ramalho, F. Ramalho, H. Martinho, and A. A. Martin D.V.M. "In vivo Raman spectroscopy for breast cancer: diagnosis in animal model", Proc. SPIE 6853, Biomedical Optical Spectroscopy, 68530O (8 February 2008); https://doi.org/10.1117/12.760089

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