Imaging of hemoglobin oxygen saturation using confocal photoacoustic system with three optical wavelengths

Guangzhi Yin; Yi Yuan

doi:10.1117/12.821591

6 March 2009 Imaging of hemoglobin oxygen saturation using confocal photoacoustic system with three optical wavelengths

Guangzhi Yin, Yi Yuan

Proceedings Volume 7280, Seventh International Conference on Photonics and Imaging in Biology and Medicine; 72802E (2009) https://doi.org/10.1117/12.821591
Event: Photonics and Optoelectronics Meetings, 2008, Wuhan, China

Abstract

In this study, a confocal photoacoustic system with double-ring senor was used for imaging the map of hemoglobin oxygen saturation (SO₂). This confocal photoacoustic system use focused optics for exploding photoacoustic signal, and the optical focus overlap with the focus of piezoelectric double-ring sensor. It has higher spatial resolution because the resolution is limited by the smaller optical focus rather than the ultrasonic focus of transducer. As near-infrared spectroscopy (NIRS), photoacoustic can distinguish oxygenated main blood chromophores such as hemoglobin (HbO₂) and deoxygenated hemoglobin (Hb), by the optical absorption at multiple optical wavelengths. Three wavelengths pulse lasers (760nm, 805nm and 850nm) were employed to excitated photoacoustic signals, and acquire photoacoustic images of the vasculature in our experiment. In phantom samples test, two kinds of ink is employed to mimic HbO₂ and Hb, respectively. The PA images of two stimulant vessels showed that the calculated maps of saturation of mixed ink agree well with the preset value of sample. The in vivo experiment demonstrates an imaging of map of SO₂ in vessels at back of mouse. These demonstrated that this confocal photoacoustic system is potentially to noninvasive, high resolution image the distribution of SO₂ in tissues.

Citation Download Citation

Guangzhi Yin and Yi Yuan "Imaging of hemoglobin oxygen saturation using confocal photoacoustic system with three optical wavelengths", Proc. SPIE 7280, Seventh International Conference on Photonics and Imaging in Biology and Medicine, 72802E (6 March 2009); https://doi.org/10.1117/12.821591

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