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It has been shown that locally resolved reflectance measurements can directly quantify scatter changes in tissues without
the need for computationally expensive model-based reconstruction schemes. Imaging systems exploiting non-model
based reconstruction schemes are faster compared to the conventional model based schemes and thus have the potential
for imaging tissue pathologies in real-time. In this report, the scanning system is described in terms of the design,
construction and testing for multi-wavelength reflectance imaging capable of measuring scatter changes with 100 micron
resolution of tissue. Imaging fields of up to 256 by 256 pixels were used in this current system, with a design for a 100
micron spot to allow sampling of the local scatter values in this size of region. Tissue phantoms with varying scattering
and absorption profiles within the region of interest were used to test the performance of this system. The results
demonstrate the ability of the instrument to measure scatter changes independent of local absorber concentration. This
new scanning system should allow visualization of tumor-associated scatter changes in situ, with full spectral resolution
across the visible range.
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Venkataramanan Krishnaswamy, P. Jack Hoopes, Kimberley S. Samkoe, Brian W. Pogue, "A raster scanning reflectance imager for non-model based quantification of tissue scatter," Proc. SPIE 6864, Biomedical Applications of Light Scattering II, 686402 (22 February 2008); https://doi.org/10.1117/12.761780