Phenomenology of optical scattering from plasmonic aggregates for application to biological imaging and clinical therapeutics

Kort Travis; Jesse Aaron; Nathan Harrison; Konstantin Sokolov

doi:10.1117/12.763869

21 February 2008 Phenomenology of optical scattering from plasmonic aggregates for application to biological imaging and clinical therapeutics

Kort Travis, Jesse Aaron, Nathan Harrison, Konstantin Sokolov

Author Affiliations +

Proceedings Volume 6869, Plasmonics in Biology and Medicine V; 68690H (2008) https://doi.org/10.1117/12.763869
Event: SPIE BiOS, 2008, San Jose, California, United States

Abstract

Near-field coupling between plasmonic resonant nanoparticles and the associated shifts in scattering spectra enables the accomplishment of unprecedented observation of the co-localization dynamics of in-situ biomolecules on nanometer length-scales. We have recently shown that resonant nanoparticles conjugated to antibodies for cell-surface receptors provide a sensitive probe allowing the unambiguous resolution of not only the time sequence, but also the details of the intracellular pathway, for receptor-mediated endocytosis in live cells. In terms of general principles, the classical electrodynamics determining the scattering cross-section for nanoparticle aggregates is straightforward. However, the specifics of the angular dependence of the differential cross-section at a single wavelength, the wavelength dependence of this cross-section, and the correct implementation and interpretation of statistical averages of cross-section properties over an ensemble of aggregate morphologies are generally quite complicated, and in fact are often misinterpreted in the literature. Despite this complexity, we have constructed a set of few-parameter formulae describing optical scattering from nanoparticle aggregates by judicious combination of experimental results with extensive, near-exact simulation using the T-matrix technique. These phenomenological results facilitate the practical use of nanoparticle aggregates for biological measurement and clinical therapeutic applications.

Citation Download Citation

Kort Travis, Jesse Aaron, Nathan Harrison, and Konstantin Sokolov "Phenomenology of optical scattering from plasmonic aggregates for application to biological imaging and clinical therapeutics", Proc. SPIE 6869, Plasmonics in Biology and Medicine V, 68690H (21 February 2008); https://doi.org/10.1117/12.763869

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available