3D microscopy of gold nanoshells in tumors using two-photon-induced photoluminescence

Jaesook Park; Arnold Estrada; Jon A. Schwartz; J. Donald Payne; Andrew K. Dunn; James W. Tunnell

doi:10.1117/12.764123

21 February 2008 3D microscopy of gold nanoshells in tumors using two-photon-induced photoluminescence

Jaesook Park, Arnold Estrada, Jon A. Schwartz, J. Donald Payne, Andrew K. Dunn, James W. Tunnell

Proceedings Volume 6869, Plasmonics in Biology and Medicine V; 68690L (2008) https://doi.org/10.1117/12.764123
Event: SPIE BiOS, 2008, San Jose, California, United States

Abstract

Gold nanoshells are a novel class of hybrid metal nanoparticles whose unique optical properties have spawned new applications including more sensitive molecular assays and cancer therapy. We report a new photo-physical property of nanoshells (NS) whereby these particles glow brightly when excited by near-infrared light. Specifically, we demonstrate NS excited at 780 nm produce strong two-photon induced photoluminescence (TPIP). We characterized the luminescence brightness of NS, comparing to that of fluorescein-labeled fluorescent beads (FB). We find that NS are 140 times brighter than FB. To demonstrate the potential application of this bright TPIP signal for biological imaging, we imaged the 3D distribution of gold nanoshells targeted to murine tumors.

Citation Download Citation

Jaesook Park, Arnold Estrada, Jon A. Schwartz, J. Donald Payne, Andrew K. Dunn, and James W. Tunnell "3D microscopy of gold nanoshells in tumors using two-photon-induced photoluminescence", Proc. SPIE 6869, Plasmonics in Biology and Medicine V, 68690L (21 February 2008); https://doi.org/10.1117/12.764123

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