Static and dynamic light scattering properties of Intralipid aqueous suspension for tissue phantom preparation and calibration

I. Delfino; R. Esposito; B. Piccirillo; G. M. Gaeta D.D.S.; M. Lepore

doi:10.1117/12.769364

21 February 2008 Static and dynamic light scattering properties of Intralipid aqueous suspension for tissue phantom preparation and calibration

I. Delfino, R. Esposito, B. Piccirillo, G. M. Gaeta D.D.S., M. Lepore

Author Affiliations +

Proceedings Volume 6870, Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurements of Tissue; 68700P (2008) https://doi.org/10.1117/12.769364
Event: SPIE BiOS, 2008, San Jose, California, United States

Abstract

Intralipid is a material widely employed for the preparation of phantoms simulating optical properties of tissues in the field of optical imaging. Two main assumptions underlie the theoretical predictions of their scattering properties: the occurrence of single scattering for any concentrations of Intralipid, thus enabling the use of Mie theory, and a highly anisotropic g-factor giving a forward preferential direction of photon propagation. The importance of precisely estimating the optical properties of such phantoms requires that the accuracy of these assumptions and their range of applicability are very well-assessed. In this paper, we report the first step of an experimental investigation on the scattering properties of Intralipid suspensions at different concentrations. The study is carried out by the joined use of Time-Resolved Transmittance and Dynamic and Static Light Scattering techniques. By the analysis of the angular and temporal dependence of light scattered by Intralipid suspensions, a more reliable description of the scattering process occurring in the samples could be obtained. The results allow us to better elucidate the dependence of scattering properties of suspensions on Intralipid concentrations and composition. This will help in the design and realization of tissue phantoms with more and more reliable optical properties.

Citation Download Citation

I. Delfino, R. Esposito, B. Piccirillo, G. M. Gaeta D.D.S., and M. Lepore "Static and dynamic light scattering properties of Intralipid aqueous suspension for tissue phantom preparation and calibration", Proc. SPIE 6870, Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurements of Tissue, 68700P (21 February 2008); https://doi.org/10.1117/12.769364

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available