Researchers at the Army Aviation and Missile Research, Development, and Engineering Center (AMRDEC) have initiated multidiscipline efforts to develop nano-based structures and components for insertion into advanced missile, aviation, and autonomous air and ground systems. The objective of the research is to exploit unique phenomena for the development of novel technology to enhance warfighter capabilities and produce precision weapons. The key technology areas that the authors are exploring include nano-based microsensors, nano-energetics, nano-batteries, nano-composites, and nano-plasmonics. By integrating nano-based devices, structures, and materials into weaponry, the Army can revolutionize existing (and future) missile systems by significantly reducing the size, weight and cost. The major research thrust areas include the development of chemical sensors to detect rocket motor off-gassing and toxic industrial chemicals; the development of highly sensitive/selective, self-powered miniaturized acoustic sensors for battlefield surveillance and reconnaissance; the development of a minimum signature solid propellant with increased ballistic and physical properties that meet insensitive munitions requirements; the development of nano-structured material for higher voltage thermal batteries and higher energy density storage; the development of advanced composite materials that provide high frequency damping for inertial measurement units' packaging; and the development of metallic nanostructures for ultraviolet surface enhanced Raman spectroscopy. The current status of the overall AMRDEC Nanotechnology research efforts is disclosed in this paper. Critical technical challenges, for the various technologies, are presented. The authors' approach for overcoming technical barriers and achieving required performance is also discussed. Finally, the roadmap for each technology, as well as the overall program, is presented.© (2011) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.