Synthesis of hematite and maghemite nanotubes and study of their applications in neuroscience and drug delivery

Linfeng Chen; Jining Xie; Kiran R. Aatre; Justin Yancey; Sahitya Chetan; Malathi Srivatsan; Vijay K. Varadan

doi:10.1117/12.881843

25 April 2011 Synthesis of hematite and maghemite nanotubes and study of their applications in neuroscience and drug delivery

Linfeng Chen, Jining Xie, Kiran R. Aatre, Justin Yancey, Sahitya Chetan, Malathi Srivatsan, Vijay K. Varadan

Author Affiliations +

Proceedings Volume 7980, Nanosensors, Biosensors, and Info-Tech Sensors and Systems 2011; 798008 (2011) https://doi.org/10.1117/12.881843
Event: SPIE Smart Structures and Materials + Nondestructive Evaluation and Health Monitoring, 2011, San Diego, California, United States

Abstract

This report discusses our work on synthesis of hematite and maghemite nanotubes, analysis of their biocompatibility with pheochromocytoma cells (PC12 cells), and study of their applications in the culture of dorsal root ganglion (DRG) neurons and the delivery of ibuprofen sodium salt (ISS) drug model. Two methods, template-assisted thermal decomposition method and hydrothermal method, were used for synthesizing hematite nanotubes, and maghemite nanotubes were obtained from the synthesized hematite nanotubes by thermal treatment. The crystalline, morphology and magnetic properties of the hematite and maghemite nanotubes were characterized by X-ray diffraction (XRD), scanning electron microscope (SEM) and vibrating sample magnetometer (VSM), respectively. The biocompatibility of the synthesized hematite nanotubes was confirmed by the survival and differentiation of PC12 cells in the presence of the hematite nanotubes coupled to nerve growth factor (NGF). To study the combined effects of the presence of magnetic nanotubes and external magnetic fields on neurite growth, laminin was coupled to hematite and maghemite nanotubes, and DRG neurons were cultured in the presence of the treated nanotubes with the application of external magnetic fields. It was found that neurons can better tolerate external magnetic fields when magnetic nanotubes were present. Close contacts between nanotubes and filopodia that were observed under SEM showed that the nanotubes and the growing neurites interacted readily. The drug loading and release capabilities of hematite nanotubes synthesized by hydrothermal method were tested by using ibuprofen sodium salt (ISS) as a drug model. Our experimental results indicate that hematite and maghemite nanotubes have good biocompatibility with neurons, could be used in regulating neurite growth, and are promising vehicles for drug delivery.

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Linfeng Chen, Jining Xie, Kiran R. Aatre, Justin Yancey, Sahitya Chetan, Malathi Srivatsan, and Vijay K. Varadan "Synthesis of hematite and maghemite nanotubes and study of their applications in neuroscience and drug delivery", Proc. SPIE 7980, Nanosensors, Biosensors, and Info-Tech Sensors and Systems 2011, 798008 (25 April 2011); https://doi.org/10.1117/12.881843

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