Guided ultrasonic waves are widely used in Structural Health Monitoring applications for inspections of large plate-like structures. Wave propagation phenomena associated with guided ultrasonic waves are difficult to model for complex engineering structures. Various simulation algorithms used in practice are not accurate and very expensive computationally. The paper demonstrates new parallel computation technology offered by modern Graphics Processing Units (GPUs) and Compute Unified Device Architecture (CUDA) used in low-cost graphical cards available in standard PCs. Such systems enable calculations of very large models in minutes. The Local Interaction Simulation Approach (LISA) algorithm have been implemented and used for wave propagation modelling. Application examples are related to structural damage detection. The results demonstrate good accuracy and effective computational performance.© (2011) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.