Simulation of microbubble response to ambient pressure changes

Klaus Scheldrup Andersen; Jørgen Arendt Jensen

doi:10.1117/12.773296

13 March 2008 Simulation of microbubble response to ambient pressure changes

Klaus Scheldrup Andersen, Jørgen Arendt Jensen

Proceedings Volume 6920, Medical Imaging 2008: Ultrasonic Imaging and Signal Processing; 692016 (2008) https://doi.org/10.1117/12.773296
Event: Medical Imaging, 2008, San Diego, California, United States

Abstract

The theory on microbubbles clearly indicates a relation between the ambient pressure and the acoustic behavior of the bubble. The purpose of this study was to optimize the sensitivity of ambient pressure measurements, using the subharmonic component, through microbubble response simulations. The behaviour of two different contrast agents was investigated as a function of driving pulse and ambient overpressure, p_ov. Simulations of Levovist using a rectangular driving pulse show an almost linear reduction in the subharmonic component as p_ov is increased. For a 20 cycles driving pulse, a reduction of 4.6 dB is observed when changing p_ov from 0 to 25 kPa. Increasing the pulse duration makes the reduction even more clear. For a pulse with 64 cycles, the reduction is 9.9 dB. This simulation is in good correspondence with measurement results presented by Shi et al. 1999, who found a linear reduction of 9.6 dB. Further simulations of Levovist show that also the shape and the acoustic pressure of the driving pulse are very important factors. The best pressure sensitivity of Levovist was found to be 0.88 dB/kPa. For Sonazoid, a sensitivity of 0.71 dB/kPa has been found, although the reduction is not completely linear as a function of the ambient pressure.

Citation Download Citation

Klaus Scheldrup Andersen and Jørgen Arendt Jensen "Simulation of microbubble response to ambient pressure changes", Proc. SPIE 6920, Medical Imaging 2008: Ultrasonic Imaging and Signal Processing, 692016 (13 March 2008); https://doi.org/10.1117/12.773296

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available