Detection and characterization of stomach cancer and atrophic gastritis with fluorescence and Raman spectroscopy

Xiaozhou Li; Junxiu Lin; Chunde Jia; Rong Wang

doi:10.1117/12.546249

4 December 2003 Detection and characterization of stomach cancer and atrophic gastritis with fluorescence and Raman spectroscopy

Xiaozhou Li, Junxiu Lin, Chunde Jia, Rong Wang

Author Affiliations +

Proceedings Volume 5255, Biomolecular Photonics and Multidimensional Microscopy; (2003) https://doi.org/10.1117/12.546249
Event: Biomolecular Photonics and Multidimensional Microscopy, 2003, Wuhan, China

Abstract

In this paper, we attempt to find a valid method to distinguish gastric cancer and atrophic gastritis. Auto-fluorescence and Raman spectroscopy of laser induced (514.5 nm and 488.0 nm) was measured. The serum spectrum is different between normal and cancer. Average value of diagnosis parameter for normal serum, red shift is less than 12 nm and Raman relative intensity of peak C by 514.5 nm excited is stronger than that of 488.0 nm. To gastric cancer, its red shift of average is bigger than 12 nm and relative intensity of Raman peak C by 514.5 nm excited is weaker than that by 488.0 nm. To atrophic gastritis, the distribution state of Raman peaks is similar with normal serum and auto-fluorescence spectrum's shape is similar to that of gastric cancer. Its average Raman peak red shift is bigger than 12 nm and the relative intensity of peak C by 514.5 excited is stronger than that of by 488.0. We considered it as a criterion and got an accuracy of 85.6% for diagnosis of gastric cancer compared with the result of clinical diagnosis.

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Xiaozhou Li, Junxiu Lin, Chunde Jia, and Rong Wang "Detection and characterization of stomach cancer and atrophic gastritis with fluorescence and Raman spectroscopy", Proc. SPIE 5255, Biomolecular Photonics and Multidimensional Microscopy, (4 December 2003); https://doi.org/10.1117/12.546249

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