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Proceedings Article

Optical and electronic design for a high-performance surface plasmon resonance imager

[+] Author Affiliations
Timothy M. Chinowsky, Tony Mactutis, Elain Fu, Paul Yager

Univ. of Washington (USA)

Proc. SPIE 5261, Smart Medical and Biomedical Sensor Technology, 173 (March 15, 2004); doi:10.1117/12.538536
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From Conference Volume 5261

  • Smart Medical and Biomedical Sensor Technology
  • Brian M. Cullum
  • Providence, RI | October 27, 2003

abstract

Surface plasmon resonance (SPR) imaging is a versatile technique for detection, quantification, and visualization of bio-molecular binding events which have spatial structure. In this paper, we describe the design principles which we are applying toward construction of a new high-performance SPR imager. We briefly review the basic principles of SPR biosensing and SPR imaging, and discuss the goals for the new design. We focus on two main goals, refractive index (RI) resolution and mechanical simplicity. We address RI resolution as a signal-to-noise issue, using simulations to determine how to maximize the signal (i.e. changes in intensity due to binding events) and minimize the noise. Specific attention is paid to the dominant effects of shot noise. Design concepts for collimating and imaging optics which reduce or eliminate the need for mechanical adjustment are presented. Ray-tracing analysis of the collimating optics is used for detailed analysis of collimator performance.

© (2004) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.
Citation

Timothy M. Chinowsky ; Tony Mactutis ; Elain Fu and Paul Yager
"Optical and electronic design for a high-performance surface plasmon resonance imager", Proc. SPIE 5261, Smart Medical and Biomedical Sensor Technology, 173 (March 15, 2004); doi:10.1117/12.538536; http://dx.doi.org/10.1117/12.538536


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