Optical and electronic design for a high-performance surface plasmon resonance imager

Timothy M. Chinowsky; Tony Mactutis; Elain Fu; Paul Yager

doi:10.1117/12.538536

15 March 2004 Optical and electronic design for a high-performance surface plasmon resonance imager

Timothy M. Chinowsky, Tony Mactutis, Elain Fu, Paul Yager

Proceedings Volume 5261, Smart Medical and Biomedical Sensor Technology; (2004) https://doi.org/10.1117/12.538536
Event: Optical Technologies for Industrial, Environmental, and Biological Sensing, 2003, Providence, RI, United States

Abstract

Surface plasmon resonance (SPR) imaging is a versatile technique for detection, quantification, and visualization of bio-molecular binding events which have spatial structure. In this paper, we describe the design principles which we are applying toward construction of a new high-performance SPR imager. We briefly review the basic principles of SPR biosensing and SPR imaging, and discuss the goals for the new design. We focus on two main goals, refractive index (RI) resolution and mechanical simplicity. We address RI resolution as a signal-to-noise issue, using simulations to determine how to maximize the signal (i.e. changes in intensity due to binding events) and minimize the noise. Specific attention is paid to the dominant effects of shot noise. Design concepts for collimating and imaging optics which reduce or eliminate the need for mechanical adjustment are presented. Ray-tracing analysis of the collimating optics is used for detailed analysis of collimator performance.

Citation Download Citation

Timothy M. Chinowsky, Tony Mactutis, Elain Fu, and Paul Yager "Optical and electronic design for a high-performance surface plasmon resonance imager", Proc. SPIE 5261, Smart Medical and Biomedical Sensor Technology, (15 March 2004); https://doi.org/10.1117/12.538536

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