Noncoherent light for PDT of spontaneous animal tumors

Michael D. Lucroy; Tisha D. Ridgway; Russell G. Higbee; Kimberly Reeds

doi:10.1117/12.527446

13 July 2004 Noncoherent light for PDT of spontaneous animal tumors

Michael D. Lucroy, Tisha D. Ridgway, Russell G. Higbee, Kimberly Reeds

Proceedings Volume 5312, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XIV; (2004) https://doi.org/10.1117/12.527446
Event: Biomedical Optics 2004, 2004, San Jose, CA, United States

Abstract

Cultured 9L cells were incubated with graded doses of pheophorbide-a-hexyl ether (HPPH) and exposed to 665 nm red light from either a noncoherent light source or a KTP-pumped dye laser. Cell death was observed after irradiation using either light source, with the noncoherent light being most effective at the highest HPPH concentrations. To determing the practicality of using the noncoherent light source for clinical PDT, dogs and cats with spontaneous tumors were injected intravenously with 0.15 mg/kg HPPH one hour before their tumors were irradiated with 665 nm noncoherent light (50 mW cm^-2, 100 J cm^-2). Of the 9 tumors treated, 8 complete responses were observed, all of which occurred in animals with squamous cell carcinoma. After 68 weeks of follow up, the median initial disease free interval had not been reached. These data support the use of noncoherent light sources for PDT of spontaneous tumors in animals, representing a cost-effective alternative to medical lasers in both veterinary and human dermatology and oncology.

Citation Download Citation

Michael D. Lucroy, Tisha D. Ridgway, Russell G. Higbee, and Kimberly Reeds "Noncoherent light for PDT of spontaneous animal tumors", Proc. SPIE 5312, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XIV, (13 July 2004); https://doi.org/10.1117/12.527446

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