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Proceedings Article

In vivo multiphoton microscopy of deep tissue with gradient index lenses

[+] Author Affiliations
Michael J. Levene, Daniel A. Dombeck, Rebecca M. Williams, Karl A. Kasischke, Raymond P. Molloy, Warren R. Zipfel, Watt W. Webb

Cornell Univ. (USA)

Jesse Skoch, Gregory A. Hickey, Martin Ingelsson, Edward A. Stern, Jochen Klucken, Brian J. Bacskai, Bradley T. Hyman

Massachusetts General Hospital (USA)

Proc. SPIE 5323, Multiphoton Microscopy in the Biomedical Sciences IV, 291 (June 21, 2004); doi:10.1117/12.537285
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From Conference Volume 5323

  • Multiphoton Microscopy in the Biomedical Sciences IV
  • Ammasi Periasamy; Peter T. C. So
  • San Jose, CA | January 24, 2004

abstract

Gradient index lenses enable multiphoton microscopy of deep tissues in the intact animal. In order to assess their applicability to clinical research, we present in vivo multiphoton microscopy with gradient index lenses in brain regions associated with Alzheimer's disease and Parkinson's disease in both transgenic and wild-type mice. We also demonstrate microscopy of ovary in wild type mouse using only intrinsic fluorescence and second harmonic generation, signal sources which may prove useful for both the study and diagnosis of cancer.

© (2004) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.
Citation

Michael J. Levene ; Daniel A. Dombeck ; Rebecca M. Williams ; Jesse Skoch ; Gregory A. Hickey, et al.
"In vivo multiphoton microscopy of deep tissue with gradient index lenses", Proc. SPIE 5323, Multiphoton Microscopy in the Biomedical Sciences IV, 291 (June 21, 2004); doi:10.1117/12.537285; http://dx.doi.org/10.1117/12.537285


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