Traditional biological and chemical methods for pathogen identification require complicated sample preparation for reliable results. The process of identification of malignant and non-malignant growths is not easier. Two new techniques of analysis of speckle-patterns, formed by histological sections with malignant and non-malignant growths illuminated by laser light, were proposed in this article. One of these techniques is based on calculation of invariant Zernike moments of speckle-field intensity spatial distribution. The second technique is based on calculation of fractal dimension of intensity spatial distribution in speckle structure. It was shown that both of these methods give the same results, which drastically depends on tissues features. Possibility of using Zernike moments and fractal dimensions, formed by laser light dispersed on histological sections, in express-diagnostics of tissues with pathological changes carrying out in vitro was investigated. Dependence of fractal dimension n conditions of irradiation of object with laser light discussed.© (2010) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.