Changes in pulmonary arterial wall mechanical properties and lumenal architecture with induced vascular remodeling

Robert C. Molthen; Amy E. Heinrich; Steven T. Haworth; Christopher A. Dawson

doi:10.1117/12.535738

30 April 2004 Changes in pulmonary arterial wall mechanical properties and lumenal architecture with induced vascular remodeling

Robert C. Molthen, Amy E. Heinrich, Steven T. Haworth, Christopher A. Dawson

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Proceedings Volume 5369, Medical Imaging 2004: Physiology, Function, and Structure from Medical Images; (2004) https://doi.org/10.1117/12.535738
Event: Medical Imaging 2004, 2004, San Diego, California, United States

Abstract

To explore and quantify pulmonary arterial remodeling we used various methods including micro-CT, high-resolution 3-dimensional x-ray imaging, to examine the structure and function of intact pulmonary vessels in isolated rat lungs. The rat is commonly used as an animal model for studies of pulmonary hypertension (PH) and the accompanying vascular remodeling, where vascular remodeling has been defined primarily by changes in the vessel wall composition in response to hypertension inducing stimuli such as chronic hypoxic exposure (CHE) or monocrotaline (MCT) injection. Little information has been provided as to how such changes affect the vessel wall mechanical properties or the lumenal architecture of the pulmonary arterial system that actually account for the hemodynamic consequences of the remodeling. In addition, although the link between primary forms of pulmonary hypertension and inherited genetics is well established, the role that genetic coding plays in hemodynamics and vascular remodeling is not. Therefore, we are utilizing Fawn-Hooded (FH), Sprague-Dawley (SD) and Brown Norway (BN)rat strains along with unique imaging methods to parameterize both vessel distensibility and lumenal morphometry using a principal pulmonary arterial pathway analysis based on self-consistency. We have found for the hypoxia model, in addition to decreased body weight, increased hematocrit, increased right ventricular hypertrophy, the distensibility of the pulmonary arteries is shown to decrease significantly in the presence of remodeling.

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Robert C. Molthen, Amy E. Heinrich, Steven T. Haworth, and Christopher A. Dawson "Changes in pulmonary arterial wall mechanical properties and lumenal architecture with induced vascular remodeling", Proc. SPIE 5369, Medical Imaging 2004: Physiology, Function, and Structure from Medical Images, (30 April 2004); https://doi.org/10.1117/12.535738

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KEYWORDS

Lung

Control systems

Arteries

Hemodynamics

Genetics

Hypoxia

Pulmonary hypertension

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