Three-dimensional photoacoustic imaging of breast tissue phantoms

Srirang Manohar; Alexei Kharine; Wiendelt Steenbergen; Ton G.J.M. van Leeuwen

doi:10.1117/12.572028

29 July 2004 Three-dimensional photoacoustic imaging of breast tissue phantoms

Srirang Manohar, Alexei Kharine, Wiendelt Steenbergen, Ton G.J.M. van Leeuwen

Proceedings Volume 5486, ALT'03 International Conference on Advanced Laser Technologies: Biomedical Optics; (2004) https://doi.org/10.1117/12.572028
Event: ALT'03 International Conference on Advanced Laser Technologies: Biomedical Optics, 2003, Silsoe, United Kingdom

Abstract

A laboratory prototype of a time-resolved photoacoustic mammograph, based on a parallel plate geometry is presented. Light is delivered from a Q-switched Nd:YAG laser using fiber-optic bundles which can be mechanically scanned across the surface of a phantom. The ultrasound signals produced by the photoacoustic effect are measured in a transmission mode, using a large-area ultrasound detector matrix. Signals from the matrix are acquired using fast digitizers. Various performance studies of the system are presented. A breast phantom of dimensions (150x120x60)mm was created based on poly(vinyl alcohol) (PVA) gel, which can be imparted with the average optical scattering properties of breast tissue by a simple process of freezing and thawing of an aqueous poly(vinyl alcohol) solution. The acoustic properties are also found to match those of breast tissue. Such a photoacoustic breast phantom was embedded with several tumour-simulating inhomogeneities. These inserts were also based on poly(vinyl alcohol) gels, appropriately dyed at the time of formation, to possess various optical absorption coefficients, between 2 and 7 times that of the background. Using the signals collected from regions-of-interest (ROI) in the volume of the phantom, three-dimensional images were obtained using a modified delay-and-sum beamforming algorithm. The results indicate that photoacoustics, as embodied in this instrument, has a potential for detecting tumours in the breast.

Citation Download Citation

Srirang Manohar, Alexei Kharine, Wiendelt Steenbergen, and Ton G.J.M. van Leeuwen "Three-dimensional photoacoustic imaging of breast tissue phantoms", Proc. SPIE 5486, ALT'03 International Conference on Advanced Laser Technologies: Biomedical Optics, (29 July 2004); https://doi.org/10.1117/12.572028

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available