The W. M. Keck Observatory Adaptive Optics (AO) team recently celebrated a milestone first AO-corrected image with the new Laser Guide Star (LGS) system. This paper details focus and pointing changes implemented for the LGS AO system. The combination of variable sodium altitude, elevation-dependent distance to the LGS, off-axis projection, and equipment flexure require both focus and pointing adjustments to keep the laser spot located and its size minimized on the wavefront sensor. We will describe the current approach to LGS focus and pointing-compensation adjustments, and provide some insight into issues seen thus far during engineering activities at the W. M. Keck Observatory.© (2004) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.