BioMEMS to bionanotechnology: state of the art in integrated biochips and future prospects

Amit Gupta; H. Li; Rafael Gomez; W.-J. Chang; Y. M. Koo; H. Chang; G. Andreadakis; Demir Akin; Rashid Bashir

doi:10.1117/12.580407

29 December 2004 BioMEMS to bionanotechnology: state of the art in integrated biochips and future prospects

Amit Gupta, H. Li, Rafael Gomez, W.-J. Chang, Y. M. Koo, H. Chang, G. Andreadakis, Demir Akin, Rashid Bashir

Proceedings Volume 5593, Nanosensing: Materials and Devices; (2004) https://doi.org/10.1117/12.580407
Event: Optics East, 2004, Philadelphia, Pennsylvania, United States

Abstract

Biomedical or Biological Micro-Electro-Mechanical- Systems (BioMEMS) have in recent years become increasingly prevalent and have found widespread use in a wide variety of applications such as diagnostics, therapeutics and tissue engineering. This paper reviews the interdisciplinary work performed in our group in recent years to develop micro-integrated devices to characterize biological entities. We present the use of electrical and mechanically based phenomena to perform characterization and various functions needed for integrated biochips. One sub-system takes advantage of the dielectrophoretic effect to sort and concentrate bacterial cells and viruses within a micro-fluidic biochip. Another sub-system measures impedance changes produced by the metabolic activity of bacterial cells to determine their viability. A third sub-system is used to detect the mass of viruses as they bind to micro-mechanical sensors. The last sub-system described has been used to detect the charge on DNA molecules as it translocates through nanopore channels. These devices with an electronic or mechanical signal output can be very useful in producing practical systems for rapid detection and characterization of cells for a wide variety of applications in the food safety and health diagnostics industries. The paper will also briefly discuss future prospects of BioMEMS and its possible impact and on bionanotechnology.

Citation Download Citation

Amit Gupta, H. Li, Rafael Gomez, W.-J. Chang, Y. M. Koo, H. Chang, G. Andreadakis, Demir Akin, and Rashid Bashir "BioMEMS to bionanotechnology: state of the art in integrated biochips and future prospects", Proc. SPIE 5593, Nanosensing: Materials and Devices, (29 December 2004); https://doi.org/10.1117/12.580407

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available