Ultrahigh-resolution endoscopic optical coherence tomography

Yu Chen; Paul R. Herz; Pei-Lin Hsiung; Aaron D. Aguirre; Hiroshi Mashimo; Saleem Desai; Macos Pedrosa; Amanda Koski; Joseph M. Schmitt; James G. Fujimoto

doi:10.1117/12.577171

18 January 2005 Ultrahigh-resolution endoscopic optical coherence tomography

Yu Chen, Paul R. Herz, Pei-Lin Hsiung, Aaron D. Aguirre, Hiroshi Mashimo, Saleem Desai, Macos Pedrosa, Amanda Koski, Joseph M. Schmitt, James G. Fujimoto

Author Affiliations +

Proceedings Volume 5630, Optics in Health Care and Biomedical Optics: Diagnostics and Treatment II; (2005) https://doi.org/10.1117/12.577171
Event: Photonics Asia, 2004, Beijing, China

Abstract

Early detection of gastrointestinal cancer is essential for the patient treatment and medical care. Endoscopically guided biopsy is currently the gold standard for the diagnosis of early esophageal cancer, but can suffer from high false negative rates due to sampling errors. Optical coherence tomography (OCT) is an emerging medical imaging technology which can generate high resolution, cross-sectional images of tissue in situ and in real time, without the removal of tissue specimen. Although endoscopic OCT has been used successfully to identify certain pathologies in the gastrointestinal tract, the resolution of current endoscopic OCT systems has been limited to 10 - 15 m for clinical procedures. In this study, in vivo imaging of the gastrointestinal tract is demonstrated at a three-fold higher resolution (< 5 m), using a portable, broadband, Cr⁴⁺:Forsterite laser as the optical light source. Images acquired from the esophagus, gastro-esophageal junction and colon on animal model display tissue microstructures and architectural details at high resolution, and the features observed in the OCT images are well-matched with histology. The clinical feasibility study is conducted through delivering OCT imaging catheter using standard endoscope. OCT images of normal esophagus, Barrett's esophagus, and esophageal cancers are demonstrated with distinct features. The ability of high resolution endoscopic OCT to image tissue morphology at an unprecedented resolution in vivo would facilitate the development of OCT as a potential imaging modality for early detection of neoplastic changes.

Citation Download Citation

Yu Chen, Paul R. Herz, Pei-Lin Hsiung, Aaron D. Aguirre, Hiroshi Mashimo, Saleem Desai, Macos Pedrosa, Amanda Koski, Joseph M. Schmitt, and James G. Fujimoto "Ultrahigh-resolution endoscopic optical coherence tomography", Proc. SPIE 5630, Optics in Health Care and Biomedical Optics: Diagnostics and Treatment II, (18 January 2005); https://doi.org/10.1117/12.577171

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
8 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Optical coherence tomography

Endoscopy

Esophagus

Image resolution

In vivo imaging

Tissues

Biopsy

Show All Keywords

Keywords/Phrases

Search In:

Publication Years