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Proceedings Article

Application of optical coherence tomography for tissue engineering

[+] Author Affiliations
Ying Yang, Alicia El Haj

Keele Univ. Medical School (United Kingdom)

Ruikang K. Wang

Cranfield Univ. at Silsoe (United Kingdom)

Elvire Guyot, Arnaud Dubois

Ecole Superieure de Physique et de Chimie Industrielles (France)

Proc. SPIE 5690, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine IX, 18 (April 19, 2005); doi:10.1117/12.592691
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From Conference Volume 5690

  • Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine IX
  • Valery V. Tuchin; Joseph A. Izatt; James G. Fujimoto
  • San Jose, CA | January 22, 2005

abstract

In the past decade, optical coherence tomography (OCT) has achieved a rapid development in clinical applications. Its capability of on-line measurement, non-destructive manner and high spatial resolution offers a great potential for tissue engineering in which the dynamic process of tissue growth need to be monitored on-line either for bulk constructs or at the cellular level. In this study, two OCT systems, time-domain Michelson interferometer based OCT (TD-OCT) and whole field OCT (WF-OCT) have been used to image poly(lactic acid) based scaffold and tissue engineered bone. It is demonstrated that TD-OCT is able to visualize the porous structure of the scaffold and its changes during culture at a macroscopic level, whilst the cells' distribution and morphology can be depicted clearly in WF-OCT. With the aid of an external contrast agent, magnetic beads, clearer cellular images have been obtained.

© (2005) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.
Citation

Ying Yang ; Ruikang K. Wang ; Elvire Guyot ; Alicia El Haj and Arnaud Dubois
"Application of optical coherence tomography for tissue engineering", Proc. SPIE 5690, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine IX, 18 (April 19, 2005); doi:10.1117/12.592691; http://dx.doi.org/10.1117/12.592691


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