Spectroscopic Fourier domain optical coherence tomography: principle, limitations, and applications

Rainer Andreas Leitgeb; Wolfgang Drexler; Boris Povazay; Boris Hermann; Harald Sattmann; Adolf Friedrich Fercher

doi:10.1117/12.592911

13 April 2005 Spectroscopic Fourier domain optical coherence tomography: principle, limitations, and applications

Rainer Andreas Leitgeb, Wolfgang Drexler, Boris Povazay, Boris Hermann, Harald Sattmann, Adolf Friedrich Fercher

Proceedings Volume 5690, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine IX; (2005) https://doi.org/10.1117/12.592911
Event: SPIE BiOS, 2005, San Jose, CA, United States

Abstract

Fourier Domain Optical Coherence Tomography (FD OCT) recently gained large reputation as a high speed imaging modality with increased sensitivity. Since the spectrum of the backscattered light is directly available, the method is a natural candidate for performing spectroscopic tissue analysis. Spectroscopic data is extracted by applying a windowed Fourier transform. The precision of the method is analyzed by measuring the absorbance of ICG samples sandwiched between microscope glass plates. A Ti:Sapph laser serves as light source with a spectral bandwidth of 160nm. For spectral analysis of tissue two distinct spectral regions are selected by multiplying the FD OCT signal spectrum with appropriate Gaussian window functions. One obtains two tomograms that enhance slightly different structures. Finally light sources of different spectral widths are synthesized and the resulting OCT tomograms that exhibit different axial resolutions are compared with respect to image quality and structure recognition.

Citation Download Citation

Rainer Andreas Leitgeb, Wolfgang Drexler, Boris Povazay, Boris Hermann, Harald Sattmann, and Adolf Friedrich Fercher "Spectroscopic Fourier domain optical coherence tomography: principle, limitations, and applications", Proc. SPIE 5690, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine IX, (13 April 2005); https://doi.org/10.1117/12.592911

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