Video compression is critical to many real world applications where the data is being transmitted over data links with limited bandwidth. Previously, information metrics have been used to assess the distortion of target signatures with differing degrees of compression. A recent update to the emerging H.264 standard, called Fidelity Range Extensions (FRExt), permits applications up to 12-bits/sample, and even monochrome only, which are especially relevant for IR applications. This paper tests this new FRExt technology on actual IR sensor data to obtain preliminary results on the compression of 12-bit IR data using state of the art video compression technology.© (2005) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.