System for the measurement of blood flow and oxygenation in tissue applied to neurovascular coupling in brain

Matthias Kohl-Bareis; Christoph Leithner; Heike Sellien; Roland Guertler; Dmitri Geraskin; Benjamin Rohrer; Georg Royl; Ulrich Dirnagl; Ute Lindauer

doi:10.1117/12.632835

7 October 2005 System for the measurement of blood flow and oxygenation in tissue applied to neurovascular coupling in brain

Matthias Kohl-Bareis, Christoph Leithner, Heike Sellien, Roland Guertler, Dmitri Geraskin, Benjamin Rohrer, Georg Royl, Ulrich Dirnagl, Ute Lindauer

Author Affiliations +

Proceedings Volume 5859, Photon Migration and Diffuse-Light Imaging II; 58590F (2005) https://doi.org/10.1117/12.632835
Event: European Conferences on Biomedical Optics 2005, 2005, Munich, Germany

Abstract

We designed a system incorporating the independent measurement of blood flow and oxygenation of haemoglobin. This is based on laser-Doppler spectroscopy with NIR wavelengths which gives a measure for changes in blood flow or tissue perfusion as well as reflectance spectroscopy in the VIS wavelength range for the calculation of the oxygenated and deoxygenated haemoglobin components. The co-registration of these parameters allows the neurovascular coupling of brain to be investigated. This is demonstrated by recording functional activity of the rat brain during electrical forepaw stimulation.

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Matthias Kohl-Bareis, Christoph Leithner, Heike Sellien, Roland Guertler, Dmitri Geraskin, Benjamin Rohrer, Georg Royl, Ulrich Dirnagl, and Ute Lindauer "System for the measurement of blood flow and oxygenation in tissue applied to neurovascular coupling in brain", Proc. SPIE 5859, Photon Migration and Diffuse-Light Imaging II, 58590F (7 October 2005); https://doi.org/10.1117/12.632835

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