Two generations of adaptive optical system for human retina imaging have been developed. The wavefront correcting elements are small PZT 19 and 37 element deformable mirrors (DM) with novel structure. The diameters of these DMs are 24 and 50mm respectively. By using these DMs, the size of whole optical system are rather small and can be fit on table. These systems are successfully used to correct the aberrations of living human eye. High-resolution images of microscopic structure in the scale of single photo-receptor cell and capillary in the human retina have been obtained by real-time correction of adaptive optical systems.© (2002) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.