Development imaging and experimental model for studying pathogenesis and treatment efficacy of postmastectomy lymphedema

Ekateryna I. Galanzha; Valery V. Tuchin; Anastasiya V. Solov'eva; Tatyana V. Stepanova; Gregory E. Brill; Vladimir P. Zharov

doi:10.1117/12.468315

23 May 2002 Development imaging and experimental model for studying pathogenesis and treatment efficacy of postmastectomy lymphedema

Ekateryna I. Galanzha, Valery V. Tuchin, Anastasiya V. Solov'eva, Tatyana V. Stepanova, Gregory E. Brill, Vladimir P. Zharov

Author Affiliations +

Proceedings Volume 4624, Optical Diagnostics and Sensing of Biological Fluids and Glucose and Cholesterol Monitoring II; (2002) https://doi.org/10.1117/12.468315
Event: International Symposium on Biomedical Optics, 2002, San Jose, CA, United States

Abstract

The experimental model was created during an abdominal dissection of the rat mesentery and ligation of the collecting vein of mesentery. It was found that mesentery edema was developed for 20-30 min. Simultaneously monitoring of main the parameters of blood and lymph flow revealed significant increasing of interstitial water amount (up to 3 times), reduction of blood microcirculation, increasing of blood vessels permeability, decreasing of lymph microvessels diameter, phasics contractions, and lymph flow velocity.

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Ekateryna I. Galanzha, Valery V. Tuchin, Anastasiya V. Solov'eva, Tatyana V. Stepanova, Gregory E. Brill, and Vladimir P. Zharov "Development imaging and experimental model for studying pathogenesis and treatment efficacy of postmastectomy lymphedema", Proc. SPIE 4624, Optical Diagnostics and Sensing of Biological Fluids and Glucose and Cholesterol Monitoring II, (23 May 2002); https://doi.org/10.1117/12.468315

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