Retinal macular pigment distribution measured by imaging fundus reflectometry

Yin Chang; Sheng-Fu Chen; Feng-Lih Lee; Shih-Jen Chen

doi:10.1117/12.469786

4 June 2002 Retinal macular pigment distribution measured by imaging fundus reflectometry

Yin Chang, Sheng-Fu Chen, Feng-Lih Lee, Shih-Jen Chen

Proceedings Volume 4625, Clinical Diagnostic Systems: Technologies and Instrumentation; (2002) https://doi.org/10.1117/12.469786
Event: International Symposium on Biomedical Optics, 2002, San Jose, CA, United States

Abstract

The existence of macular pigment (MP) in human eyes has been found to be of importance in the prevention of age-related macular degeneration (ARMD). A non-invasive technique of two-wavelength (460 nm and 560 nm) imaging fundus reflectometry was developed to measure the density distribution of this yellow pigment in retina in vivo. A total of 54 healthy human subjects were recruited and divided into three groups, which had average ages and sample sizes of 24.8+/- 2.6 (N=24), 40.2+/- 8.3 (N=13) and 67.5+/- 7.1 years (N=17) respectively. The MP distributions only in the horizontal meridian, which are fitted by Gaussian equation are presented in this report. The results show that the average peak MP densities are 0.48+/- 0.17, 0.46+/- 0.21 and 0.52+/- 0.13 in density unit (DU) from young to old groups respectively. No significant difference is shown in the statistical t-test between the groups of the MP density. The half MP distribution width (covers 95% of Gaussian area) are 5.4 degree(s)+/- 1.6 degree(s), 5.7 degree(s)+/- 2.3 degree(s) and 7.9+/- +/- 2.1 degree(s) from young to old groups respectively. It shows that the area of MP is increased approximately by a rate of 0.06 degree(s)/year. However, the cause of the MP extension in the retina with respect to age is unknown.

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Yin Chang, Sheng-Fu Chen, Feng-Lih Lee, and Shih-Jen Chen "Retinal macular pigment distribution measured by imaging fundus reflectometry", Proc. SPIE 4625, Clinical Diagnostic Systems: Technologies and Instrumentation, (4 June 2002); https://doi.org/10.1117/12.469786

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KEYWORDS

Reflectivity

Reflectometry

Retina

Absorbance

Data modeling

Eye

Absorption

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