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Proceedings Article

Database comprising biomolecular descriptors relevant to protein adsorption on microarray surfaces

[+] Author Affiliations
Dan V. Nicolau

Univ. of Melbourne (Australia)

Dan V. Nicolau, Jr.

Swinburne Univ. of Technology (Australia)

Proc. SPIE 4626, Biomedical Nanotechnology Architectures and Applications, 109 (June 19, 2002); doi:10.1117/12.472070
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From Conference Volume 4626

  • Biomedical Nanotechnology Architectures and Applications
  • Darryl J. Bornhop; David A. Dunn; Raymond P. Mariella, Jr.; Catherine J. Murphy; Dan V. Nicolau; Shuming Nie; Michelle Palmer; Ramesh Raghavachari
  • San Jose, CA | January 19, 2002

abstract

The adsorption of biomolecules on surfaces is dependent on biomolecule molecular descriptors, surface descriptors and environment descriptors. Of these descriptors, the biomolecular-related are the most complex and arguably the most important, as being related to both adsorption and possible denaturation on surfaces. The criticality of biomolecule adsorption in the context of microarrays and microfluidics devices will increase with the advancement of proteomics that probes the functionality of proteins, which are much more responsive to surfaces than DNA - the focal biomolecule of genomics. Anticipating this development, the present contribution proposes the establishment of a biomolecular descriptors database, which could be the starting point for a depositary of data and a source of validation for predictive models for adsorption and denaturation.

© (2002) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.
Citation

Dan V. Nicolau and Dan V. Nicolau, Jr.
"Database comprising biomolecular descriptors relevant to protein adsorption on microarray surfaces", Proc. SPIE 4626, Biomedical Nanotechnology Architectures and Applications, 109 (June 19, 2002); doi:10.1117/12.472070; http://dx.doi.org/10.1117/12.472070


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