Pd tetrabenzoporphyrin-dendrimers: near-infrared phosphors for oxygen measurements by phosphorescence quenching

Sergei A. Vinogradov; Evelyn Kim; David F. Wilson

doi:10.1117/12.472081

21 June 2002 Pd tetrabenzoporphyrin-dendrimers: near-infrared phosphors for oxygen measurements by phosphorescence quenching

Sergei A. Vinogradov, Evelyn Kim, David F. Wilson

Author Affiliations +

Proceedings Volume 4626, Biomedical Nanotechnology Architectures and Applications; (2002) https://doi.org/10.1117/12.472081
Event: International Symposium on Biomedical Optics, 2002, San Jose, CA, United States

Abstract

Phosphorescence quenching is an optical method for measuring tissue oxygenation. The technique is based on the quenching of phosphorescence originated from the injected dye by molecule oxygen dissolved in the medium. The phosphor is the only 'invasive' component of the measurement procedure, and thus it is important to have precise control over the bio- distribution of the phosphor, i.e. to confine it to a single compartment within the sample. For tissue applications the phosphor must also be an effective light absorber in the near IR and to exhibit oxygen quenching constant of 200-400 Torr^-1 sec^-1, to permit reliable quantification of oxygen in arterioles as well as in veins. Overall, it is desirable to have synthetic, inert, hydrophilic, phosphors with quenching characteristics that are not affected by molecules other than oxygen. We discuss a new generation of phosphors based on dendrimer- tetrabenzoporphyrins, designed to satisfy the above criteria. In these phosphors, the core metallotetrabenzoporphyrins prove the required physical characteristics, while their immediate surrounding environments consist of covalently attached dendritic branches. The dendritic cages around porphyrins control their quenching properties and protect porphyrins from interactions with other substances in the blood.

Citation Download Citation

Sergei A. Vinogradov, Evelyn Kim, and David F. Wilson "Pd tetrabenzoporphyrin-dendrimers: near-infrared phosphors for oxygen measurements by phosphorescence quenching", Proc. SPIE 4626, Biomedical Nanotechnology Architectures and Applications, (21 June 2002); https://doi.org/10.1117/12.472081

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